Natural, Herbal, Clinically Proven Arthritis Relief

How the Herbs in RZN Relief Products Work

ARTHRI-ZEN PRODUCT LINE

Juniper:

Compounds in Juniper block production of slow fiber (C-fiber) (+) neurotransmitters (NT’s) and possibly increase the presence of inhibitory (-) NT’s, thus reducing chronic pain signals to the brain. Some of these same compounds (sesquiterpene lactones among them) may reduce the migration of Substance P, a pain signal enhancer, from the dorsal horn of the spinal column to the peripheral nerve fibers.

Polyterpenoid compounds reduce production of prostacyclin synthetase, the enzyme needed to produce prostacyclin, one of the most aggressive of all prostaglandins, and platelet activation factor (PAF), an inflammatory compound. Prostacyclin hypersensitizes peripheral pain receptors. Thus, by reducing prostacyclin levels in the tissues pain receptors are desensitized.

Volatile oil components (4-terpineols) act as mild nephritic tissue irritants and thus increase glomerular filtration rate in the kidneys, creating a mild diuretic action.

Inflammation and pain are therefore reduced by interfering with the action of what’s there, blocking production of more, and helping the body get rid of the rest through increased diuresis.

Goldenrod:

Goldenrod is an aquaretic, increasing renal blood flow and glomerular filtration rate without stimulating the loss of electrolytes such as sodium and chloride. Aquaretics are considered safer than many synthetic diuretics that promote the loss of electrolytes. This effect adds to the diuretic action of Juniper.

Goldenrod has strong anti-inflammatory activity, attributed to flavonoids such as rutin, quercitrin, isoquercitrin, astragalin, and nicotiflorin.

Dandelion:

Dandelion's diuretic action is probably the result of sesquiterpene lactones. The leaves are a rich source of potassium, which may make it the only naturally occurring potassium-sparing diuretic, although its diuretic action is likely different from that of pharmaceuticals. At very high doses, the leaves have been shown to possess diuretic effects comparable to the prescription diuretic frusemide (Lasix).

Anti-edemic effects are the result of many phytochemicals, among them beta-amyrin and caffeic acid.

Dandelion is also a rich source of vitamins and minerals. The leaves have a very high content of vitamin A as well as moderate amounts of vitamin D, vitamin C, various B vitamins, iron, silicon, magnesium, zinc, and manganese

Meadowsweet:

Meadowsweet was one of the three most sacred plants used by Celtic Druids. The analgesic substance salicin was first isolated from Meadowsweet in 1827. Salicylic acid was first synthesized in 1859 and provided the basis for the commercial synthesis of acetyl salicylic acid, commonly known as aspirin. The word aspirin owes its origin to the original genus name of Meadowsweet, Spiraea, having been coined from “a” (for acetyl, a chemical group) and “spirin” (from Spiraea).

The presence of aspirin-like chemicals explains Meadowsweet's action in reducing fever and relieving the pain of rheumatism in muscles and joints. Herbalists have long held that natural aspirin-like compounds acting together have a gentler, more long-lasting pharmacological effect than the synthetic aspirin.

Meadowsweet also contains many of the anti-inflammatory phytochemicals noted in connection with other herbs above.

Willow:

Willow, like meadowsweet, is a source of natural aspirin-like compounds collectively known as salicins.

MIGRA-ZEN RELIEF PLUS

The intimal endothelium of the vasculature is vested with sensory receptors (nerve endings). These nerve endings provide feedback to the brain about what is happening around the body to a very critical system. Outside of the cranium the endothelium is lined with thermal, chemical, and mechanical sensors to indicate the three major categories of injury to the "sealed" vasculature. Within the cranium however, there is almost no need for chemical and thermal sensors, and so the overwhelming majority of the sensory nerve endings are of the mechanical type. These are used to indicate a physical disruption to the patency of the vascular wall.

During a migraine vasospasm is a response to the release of serotonin, norepinephrine, and perhaps other biochemicals as well. Although there is no injury per se to the vasculature, the spasms are interpreted by the sensors as a physical injury and they fire off, sending what is interpreted by the brain as pain signals.

Juniper is known to be a mild smooth muscle irritant which affects muscle tone. By altering the basal muscle tone of the cerebrovasculature very slightly the smooth muscle walls of these vessels are beyond the vasoconstrictive/vasodilatory effects of serotonin and norepinephrine, thus easing cranial vasospasm and the ensuing pain

Goldenrod, Meadowsweet, and Dandelion are known among herbalists for their anti-inflammatory properties. Some schools of thought about migraines point to an increase in inflammation as a contributing cause of the symptomology.

Meadowsweet and Willow contain a variety of salicin compounds that have some of the analgesic properties associated with aspirin.

All RZN Formulas

Grape Extract.

Research has clearly demonstrated that simple fruit sugars enter the bloodstream many times faster than complex sugars. When pharmacologically active herbal compounds in RZN Relief products are complexed to the sugars, the sugar acts as a carrier (a shield you might say) that allows rapid absorption in the intestines.

When herbal compounds are digested in the usual fashion, they are broken down into fragments in order for absorption into the portal vein to take place. This fragmentation not only robs them of pharmacological activity, but often causes them to be taken for foreign ‘toxins’ by the liver, which promptly filters them out. This results in very little getting to the place where it’s needed.

But, when the sugar-herbal complexes in RZN products enter the blood, they do so without suffering attack by digestive enzymes and acids. They rehydrolyze, allowing the sugar to split off to be metabolized in the usual fashion and the herbal compounds to find their way to the site of injury. This allows the herbal compounds to be delivered to the bloodstream more completely than any other delivery system, with essentially 100% of their pharmacological activity intact.

The grape extracts used in RZN products also contain numerous analgesic and anti-inflammatory compounds such as ferulic and gentisic acids, kaempferol glucosides, salicylic acids, vitamin C, cinnamic acid, coumarin, myricetin, quercitin, quercitrin, and resveratrol, which synergistically add to the pharmacological effects of the herbal ingredients.

Although the level of herbs in is very low, the overall effect is strong because the pharmacological properties of the various phytochemicals ‘synergistically amplify’ each other.


Products - Arthri-Zen Relief - With MSM - Migra Zen Relief Plus Information - Arthri-Zen Relief Facts - Migra-Zen Relief PLUS Facts - Research - Allergic Reactions - Benefits of RZN Products - Arthri-Zen Relief vs COX-2 Inhibitors - About Us - Contact Us Testimonials - Arthri-Zen Relief - Migra-Zen Relief PLUS - Health and Medical Professionals - Celebrities Ingredients - Juniper - Goldenrod - Dandelion - Meadowsweet - Willow How to Use - Using Arthri-Zen Relief - Using Migra-Zen Relief PLUS - Arthri-Zen Relief for Athletes Home Page	How the Herbs in RZN Relief Products Work En Español *ARTHRI-ZEN PRODUCT LINE* *Juniper:* Compounds in Juniper block production of slow fiber (C-fiber) (+) neurotransmitters (NT’s) and possibly increase the presence of inhibitory (-) NT’s, thus reducing chronic pain signals to the brain. Some of these same compounds (sesquiterpene lactones among them) may reduce the migration of Substance P, a pain signal enhancer, from the dorsal horn of the spinal column to the peripheral nerve fibers. Polyterpenoid compounds reduce production of prostacyclin synthetase, the enzyme needed to produce prostacyclin, one of the most aggressive of all prostaglandins, and platelet activation factor (PAF), an inflammatory compound. Prostacyclin hypersensitizes peripheral pain receptors. Thus, by reducing prostacyclin levels in the tissues pain receptors are desensitized. Volatile oil components (4-terpineols) act as mild nephritic tissue irritants and thus increase glomerular filtration rate in the kidneys, creating a mild diuretic action. Inflammation and pain are therefore reduced by interfering with the action of what’s there, blocking production of more, and helping the body get rid of the rest through increased diuresis. *Goldenrod:* Goldenrod is an aquaretic, increasing renal blood flow and glomerular filtration rate without stimulating the loss of electrolytes such as sodium and chloride. Aquaretics are considered safer than many synthetic diuretics that promote the loss of electrolytes. This effect adds to the diuretic action of Juniper. Goldenrod has strong anti-inflammatory activity, attributed to flavonoids such as rutin, quercitrin, isoquercitrin, astragalin, and nicotiflorin. *Dandelion:* Dandelion's diuretic action is probably the result of sesquiterpene lactones. The leaves are a rich source of potassium, which may make it the only naturally occurring potassium-sparing diuretic, although its diuretic action is likely different from that of pharmaceuticals. At very high doses, the leaves have been shown to possess diuretic effects comparable to the prescription diuretic frusemide (Lasix). Anti-edemic effects are the result of many phytochemicals, among them beta-amyrin and caffeic acid. Dandelion is also a rich source of vitamins and minerals. The leaves have a very high content of vitamin A as well as moderate amounts of vitamin D, vitamin C, various B vitamins, iron, silicon, magnesium, zinc, and manganese *Meadowsweet:* Meadowsweet was one of the three most sacred plants used by Celtic Druids. The analgesic substance salicin was first isolated from Meadowsweet in 1827. Salicylic acid was first synthesized in 1859 and provided the basis for the commercial synthesis of acetyl salicylic acid, commonly known as aspirin. The word aspirin owes its origin to the original genus name of Meadowsweet, Spiraea, having been coined from “a” (for acetyl, a chemical group) and “spirin” (from Spiraea). The presence of aspirin-like chemicals explains Meadowsweet's action in reducing fever and relieving the pain of rheumatism in muscles and joints. Herbalists have long held that natural aspirin-like compounds acting together have a gentler, more long-lasting pharmacological effect than the synthetic aspirin. Meadowsweet also contains many of the anti-inflammatory phytochemicals noted in connection with other herbs above. *Willow:* Willow, like meadowsweet, is a source of natural aspirin-like compounds collectively known as salicins. MIGRA-ZEN RELIEF PLUS The intimal endothelium of the vasculature is vested with sensory receptors (nerve endings). These nerve endings provide feedback to the brain about what is happening around the body to a very critical system. Outside of the cranium the endothelium is lined with thermal, chemical, and mechanical sensors to indicate the three major categories of injury to the "sealed" vasculature. Within the cranium however, there is almost no need for chemical and thermal sensors, and so the overwhelming majority of the sensory nerve endings are of the mechanical type. These are used to indicate a physical disruption to the patency of the vascular wall. During a migraine vasospasm is a response to the release of serotonin, norepinephrine, and perhaps other biochemicals as well. Although there is no injury per se to the vasculature, the spasms are interpreted by the sensors as a physical injury and they fire off, sending what is interpreted by the brain as pain signals. *Juniper* is known to be a mild smooth muscle irritant which affects muscle tone. By altering the basal muscle tone of the cerebrovasculature very slightly the smooth muscle walls of these vessels are beyond the vasoconstrictive/vasodilatory effects of serotonin and norepinephrine, thus easing cranial vasospasm and the ensuing pain *Goldenrod, Meadowsweet, and Dandelion* are known among herbalists for their anti-inflammatory properties. Some schools of thought about migraines point to an increase in inflammation as a contributing cause of the symptomology. *Meadowsweet* and *Willow* contain a variety of salicin compounds that have some of the analgesic properties associated with aspirin. All RZN Formulas *Grape Extract.* Research has clearly demonstrated that simple fruit sugars enter the bloodstream many times faster than complex sugars. When pharmacologically active herbal compounds in RZN Relief products are complexed to the sugars, the sugar acts as a carrier (a shield you might say) that allows rapid absorption in the intestines. When herbal compounds are digested in the usual fashion, they are broken down into fragments in order for absorption into the portal vein to take place. This fragmentation not only robs them of pharmacological activity, but often causes them to be taken for foreign ‘toxins’ by the liver, which promptly filters them out. This results in very little getting to the place where it’s needed. But, when the sugar-herbal complexes in RZN products enter the blood, they do so without suffering attack by digestive enzymes and acids. They rehydrolyze, allowing the sugar to split off to be metabolized in the usual fashion and the herbal compounds to find their way to the site of injury. This allows the herbal compounds to be delivered to the bloodstream more completely than any other delivery system, with essentially 100% of their pharmacological activity intact. The grape extracts used in RZN products also contain numerous analgesic and anti-inflammatory compounds such as ferulic and gentisic acids, kaempferol glucosides, salicylic acids, vitamin C, cinnamic acid, coumarin, myricetin, quercitin, quercitrin, and resveratrol, which synergistically add to the pharmacological effects of the herbal ingredients. Although the level of herbs in is very low, the overall effect is strong because the pharmacological properties of the various phytochemicals ‘synergistically amplify’ each other.